2026 Late-Breaking Clinical Trials & Science

Chairs:

Susan P. Etheridge, MD, FHRS, CEPS-P
Rakesh Gopinathannair, MBA, MD, FHRS

HRS COMPASS QI Initiative — Centers of Excellence Optimal Management Pathways for AFib Specialty Services Early Rhythm Control Treatment Care Pathway: Primary Results

REAL AF Registry — Variable Loop Circular Catheter Pulsed Field Ablation in Real-World Practice — Low Complication Rates Across Patient and Procedural Characteristics

ALONE-AF Substudy — Cognitive Function and Anticoagulation Discontinuation in Patients Without Long-Term Recurrence After Catheter Ablation for AFib

NOAH-AFNET 6 Trial — Distribution of Atrial Fibrillation Burden, Relation to Outcomes, and Effectiveness and Safety of Anticoagulation Based on Device Reports

Chairs:

Sana M. Al-Khatib, MD, MHS, FHRS
Andrew D. Krahn, MD, FHRS

PRAETORIAN-DFT Trial — A Randomized Comparison of Subcutaneous ICD Implantation With or Without Defibrillation Testing

LEAP2 — First-In-Human Study of a Chronically Implanted Novel Leadless Pacemaker for Conduction System Pacing

ASCEND CSP Trial — Safety and Efficacy of a Novel ICD Lead for Left Bundle Branch Area Pacing

Enlighten Post-Approval Registry — Real-World Experience with the Extravascular ICD Through One Year

Chairs:

Kamala P. Tamirisa, MD, FHRS
Daniel P. Morin, MD, MPH, FHRS

AVANT GUARD — Pulsed Field Ablation versus Anti-Arrhythmic Drug Therapy as First-Line Treatment for Persistent AFib: A Prospective Randomized Multicenter Global Study

Sphere-9 VT Early Feasibility Study — Six-Month Outcomes with a Dual-Energy Lattice-Tip Mapping and Ablation Catheter for Ventricular Tachycardia Treatment

FlexPulse IDE Study — Safety and Effectiveness of a Dual-Energy Focal Ablation Catheter to Treat Paroxysmal AFib: 6-Month Results

Nanosecond PFA Multicenter Experience — One-Year Outcomes of Nanosecond Pulse Field Ablation Using a Compliant Circular Catheter to Treat AFib

Chairs:

Jagmeet P. Singh, MD, PhD, FHRS
Luigi Di Biase, MD, PhD, FHRS

FULCRUM-VT Trial — Effectiveness and Safety of Ultra-Low Temperature Ablation of Ventricular Tachycardia in Patients with Structural Heart Disease

CAAD-VT Trial — Catheter Ablation versus Anti-Arrhythmic Drugs for Ventricular Tachycardia in Ischaemic and Non-Ischaemic Cardiomyopathy: A Multicenter Randomized Controlled Trial

Dual-Energy Lattice-Tip Catheter Early U.S. Experience — Catheter Ablation of Ventricular Arrhythmias

Proton Beam Cardiac Radioablation — Results from a First-in-Human, Prospective, Non-Randomized Trial for Refractory Ventricular Tachycardia

Chairs:

Mina K. Chung, MD, FHRS
Dhanunjaya R. Lakkireddy, MBA, MD, FHRS

CHAMPION-AF Sub-Analysis — Outcomes of Left Atrial Appendage Closure vs. Oral Anticoagulation in Patients with AFib and Prior Ablation

ASAP-TOO Trial — Long-Term Outcomes After Left Atrial Appendage Closure in Anticoagulation-Ineligible AFib Patients

The EXT Study — Three-Year Outcomes from a Multicenter Randomized Controlled Study Re-defining a Cornerstone Strategy for Persistent AFib Ablation

CAPT-AF Trial — Ablation Pursuing AFib Termination as a Procedural Endpoint versus Prespecified Ablation Strategy Followed by Cardioversion in Persistent AFib